Abstract: Transition metal phosphides have recently been reported as a new class of highactivity hydrodesulfurization (HDS) and hydrodenitrogenation (HDN) catalysts. Among them, Ni2P has better HDS and HDN activity. The surface area of unsupported Ni2P catalysts is rather low (< 1m2/g). To increase the active surface area, the dispersion of Ni2P on a highsurface support is needed. SiO2 is widely used as support of the Ni2P catalysts. TiO2 is commonly used as support of catalysts. It can cause strong interaction with metal, that facilitates disperse of active components on its surface. In this paper, a series of supported Ni2P catalysts on TiO2 were prepared via temperatureprogrammed reduction. The structure characteristics of samples have been characterized by means of Xray powder diffraction（XRD），N2 adsorption (BET) and temperatureprogrammed reduction (H2TPR). Benzene hydrogenation was chosen as a model reaction to investigate the influences of Ni loading, initial Ni/P mole ratio. Results showed that Ni2P was the main phase on the TiO2 supported catalysts. Ni2P/TiO2 catalysts had high activity with 100% cyclohexane selectivity and excellent stability in benzene hydrogenation reaction. The preparation factors had great effects on the activity of benzene hydrogenation reaction. With the increase of Ni2P loading，the activity of the Ni2P/TiO2 catalyst increased firstly and then decreased. Benzene conversion reached a maximum with Ni2P loading of about 12%. The activity and stability of the Ni2P/TiO2 catalysts were also affected profoundly by the initial phosphorus content. With the increase of the initial P/Ni mole ratio，the reaction stability is better，but the steady activity increased firstly and then decreased. In comparison with Ni2P/SiO2, Ni2P/TiO2 catalysts had much better activity and stability in benzene hydrogenation reaction.