Abstract: With ongoing global warming and increain energy demands, the CH₄-CO₂ reforming reaction (dry reforming of methane, DRM) has garnered significant attention as a promising carbon capture and utilization technology. Nickel-based catalysts are renowned for their outstanding activity and selectivity in this process. The impact of metal-support interaction (MSI), on Ni-based catalyst performance has been extensively researched and debated recently. This paper reviews the recent research progress of MSI on Ni-based catalysts and their characterization and modulation strategies in catalytic reactions. From the perspective of MSI, the effects of different carriers (metal oxides, carbon materials and molecular sieves, etc.) are introduced on the dispersion and surface structure of Ni active metal particles, and the effect of MSI on the activity and stability of DRM reactions on Ni-based catalysts is discussed in detail. Future research should focus on better understanding and controling MSI to improve the performance and durability of Nickel-based catalysts in CH₄-CO₂ reforming ,advancing cleaner energy technologies.