Abstract: In order to promote mass transfer and realize products separation from slurry, reaction performance of CuCr/CH3ONa catalyst used for the lowtemperature methanol synthesis was firstly examined in the bubble column slurry reactor with a flash column(BCSR/FC). The reaction system includes the reaction section of 39mm id. and 4800mm height and the enlarged section of 147mm id and 1200mm height in BCSR,FC of 147mm id. and 1640mm height and a slurry recirculating pump. The initial slurry was composed of the required amounts of sodium methoxide solution and CuCr catalyst and emulsifier OP10 as well as the balanced liquid xylene medium. The results showed that the BCSR/FC can be operated at 4.2MPa~4.6MPa,110℃~120℃ (reaction section)and 100℃~110℃(enlarged section),inlet gas velocity 0.35cm/s~0.40cm/s for BCSR, 0.25MPa~0.4MPa, 80℃~90℃ for FC and slurry recirculation rate of 50L/h. The results showed that the conversions of CO+H2, CO and H2 were decreased from their highest of 71.0%,79.1% and 67.5% to 17.8%, 35% and 12.1% during operation test over 100h respectively. The stability of the catalyst system is poor although its initial activity is quite high.This is probably due to the consumption of CH3ONa caused by the side reaction CH3ONa + HCOOCH3→CH3OCH3 + HCOONa. Liquid products were composed of DME of 1.23%, methanol of 79.52% and MeF of 19.25%. Selectivity of Methanol + MeF is more than 98%.Its yields were 0.168g/g cat·h based on all CuCr catalyst in the system and 0.336 g/gcat·h only based on the CuCr catalyst in BCSR.