Abstract: The CuO-ZnO-Al₂O₃/HZSM-5 catalyst prepared by co-precipitation and mechanical mixing with HZSM-5 was used for hydrogen production from steam reforming of dimethyl ether. The effects of Cr, Zr, Co and Ce promoters on catalyst performance were investigated by means of X-ray diffraction(XRD), temperature programmed reduction (H₂-TPR), SEM and BET. The results showed that addition of promoter Cr can reduce the average pore diameter and reduction temperature of catalyst effectively, and inhibited the form of Zn(OH)₂ in the catalyst preparation process. The conversion of dimethyl ether and hydrogen yield reaches 99% and 95% respectively at low reaction temperature. The effects of reaction termperature, space velocity and steam-to-DME ratio were investigated. At the conditions of 250℃, the space velocity of 3884mL/(g.h), H₂O/DME=5, over 97% of DME conversion was obtained over the CuO-ZnO-Al₂O₃-Cr₂O₃/HZSM-5 catalyst and the catalytic activity has no obvious deactivation during 50h durability test.