Abstract: A new set of reduced global mechanism with NOx formation has been developed for methane oxidation from the detailed mechanism GRI2-11 using a computer algorithm for automatic generation of reduced chemistry, after selecting the non-steady-state species. The global mechanism, consisting of 18 species and 14 lumped reaction steps, is based on the sensitivity analysis and the quasi-steady-state approximation. The 14-step reduced mechanism is then used in perfectly stirred reactor and laminar premixed flame, the results show that it exhibits good to excellent performance in predicting a wide range of combustion phenomena and the formation of NO under extensive thermodynamic parametric variations, compared with the results of the detailed mechanism GRI2.11.