Abstract: In the study of the application of high-density fuel HDF-1, the compatibility of rubbers used in the system with fuel HDF-1 is one of important issues because it directly affects the storage, transportation and use of fuel HDF-1. This paper reports the effects of fuel HDF-1 on the rubbers such as nitrile rubber 4170, nitrile rubber 5171, fluorinated silicone rubber G402 and container rubber at room temperature or 70 ℃ and comparison of the results with No.3 jet fuel (RP-3).The rubbers were characterized by FTIR. The results show that fluorinated silicone rubber G402 and container rubber are compatible with fuel HDF-1 and fuel RP-3. Fuel HDF-1 is less compatible with nitrile rubber 5171 than fuel RP-3, and fuel HDF-1 is least compatible with nitrile rubber 4170. Therefore, nitrile rubber 4170 and nitrile rubber 5171 are not suitable for the storage and transportation of fuel HDF-1, the rubbers used in the fuel RP-3 system cannot be directly used in the fuel HDF-1 system.