Abstract: The products from Fischer-Tropsch synthesis process, without S, N and aromatic hydrocarbons, are clean and environmentally friendly. But they contain a large number of alkene and oxygenates, especially acid oxygenates, which erode equipment and need to be hydrorefined. Therefore, the study on the novel hydrodeoxygenation catalysts for F-T synfuels is of great significance. Hydrodeoxygenation of oxygenates (n-butanonide，butyric acid and butanone) and intermediate products were investigated over Ni-M/γ-Al2O3（M=Co, Cu, Fe, La）catalysts. The influences of reducing behavior and surface dispersion of the catalysts on the catalytic performance were intensively studied. The results show that Cu and La facilitate the reduction of the NiO, but adding Co makes it difficult to be reduced. Co, Cu, Fe and La all increase the dispersion degree of NiO on the surface of the catalysts in the order of Co>Fe>La>Cu, which can improve the catalytic activity. The Ni/γ-Al2O3 catalysts added different metals show different activity and selectivity. Nickelbased catalyst with Fe as a promoter demonstrates better activity to butyric acid；adding La in nickel-based catalyst results in better performance of hydrodeoxygenation to n-butanonide； nickel-based catalyst with Co metal is more beneficial to improve the deoxygenation to butanone. Besides, n-butanonide and butyric ester are intermediate products in the course of hydrogenation of butyric acid.