Abstract: In order to develop a new process of low-temperatutre methanol synthesis, reaction performance of the low-temperature methanol synthesis catalyst CuCr/CH3ONa was examined in the bubble column slurry reactor (BCSR)of 40 mm in diameter and 4 500 mm height. The slurry was composed of the required amounts of sodium methoxide solution, CuCr catalyst and emulsifier OP-10, as well as the balanced liquid xylene medium. The results showed that the average conversion of CO was 78% in 90 ℃~110 ℃, 4.8 MPa and operation gas velocity 0.2 cm/s during first 9 h of operation test. Methanol was main product from BCSR. Compared with the results of the test in the autoclave, efficiency of BCSR is about 80% of the autoclave reactor’s. This is probably due to the consumption of CH3ONa and the negative effect of emulsifier OP-10. Results demonstrated the feasibility of the application of BCSR in low temperature methanol synthesis in slurry.