Abstract: The simulation of producing acetone and methanol from water phase product of Fischer-Tropsch synthesis was carried out by the software of ASPEN PLUS(model version 11.1). Under different conditions, the simulation and optimization of the distillation columns were made and the optimal operation parameters of the whole process were obtained. Extractive distillation column: the volume ratio of solvent to feed is 1.00, the mass ratio of distillation to feed is 4.56%, the reflux ratio of mass is 2.00, the numbers of theory stage of extractive distillation column is 36, the numbers of solvent stage of extractive distillation column is 8 and the numbers of feed stage of extractive distillation column is 18, the optimal temperature of feed is 325.15K and one is 328.25K for the solvent water. Solvent recovery column: the mass ratio of distillation to feed is 42.10%, the reflux ratio of mass is 1.00, the numbers of theory stage of solvent recovery column is 19, and the numbers of feed stage of solvent recovery column is 13. Through the comparison of data between simulation and experiments, the reliability of simulation was testified.