Abstract: A series of catalysts were prepared by calcination of copper(II) hydroxide and pseudo boehmite with a Cu/Al molar ratio of 1/2. When the calcination temperature was raised from 500 ℃ to 900 ℃, the main component of the catalysts varied from CuO to CuAl₂O₄, and the catalyst surface area declined from 75.0 to 16.6 m²/g. The catalysts, with CuAl₂O₄ as main component and high surface area, showed excellent catalytic performance in methanol steam reforming reaction (MSR). In addition, the catalyst, with CuAl₂O₄ as main component, had the copper releasing as well as sintering, hence the catalytic activity increased first and then decreased. The preferred catalyst was calcined at 800 ℃ and had better catalytic performance than commercial Cu-Zn-Al. Meanwhile, this catalyst can be regenerated after MSR. When the catalyst was not pre-reduced, the methanol conversion was 55.2% at the beginning, and then increased to 79.3% at 288.3 h, and decreased to 63.9% at 1 000.5 h, when reaction conditions were the molar ratio of alcohol to water 1, 240 ℃, 1.0×10⁶ Pa, WHSV of 1.75 h^-1.