Abstract: The epoxidized biodiesel (EBD) was prepared with biodiesel (BD) as raw material, which was then subjected an etherification ring opening reaction with 2-ethyl hexanol over the D001 resin catalyst; the resultant product can be used as the lubricant base stock. The products and material used were characterized by FT-IR and TG; the properties of as synthesized lubricant base stock were compared with those of EBD and the lubricant from 150SN mineral oil. The results showed that the as-synthesized lubricant base stock is excellent in terms of thermal stability, viscosity-temperature behavior, viscosity index, oxidation stability, and wear resistance and loading capacity. Moreover, D001 resin as a catalyst exhibits good reusability; it remains high active after being used for five times.