Abstract: M/CuO/CeO₂ (M=Cr, Zn, Y, La) catalyst was prepared by sequential impregnation method. The catalysts were characterized by XRF, XRD, BET, H₂-TPR and XPS. The effects of different promoters on the structure and properties of CuO/CeO₂ catalysts were investigated.The results show that the doping of promoters mainly affects the dispersion of CuO, the reduction properties of the catalyst, the interaction between CuO and CeO₂, and the oxygen hole content on the surface of the catalyst. After doping additives Cr and Zn, improving the dispersion of CuO on catalysts, and the interaction between CuO and CeO₂ strengthens, the surface oxygen holes increase, which in turn increases the catalytic activity. After doping the additives Y and La, decreasing the dispersion of CuO on catalysts, the interaction between CuO and CeO₂ is weakened, and the surface oxygen holes are reduced, thus the catalytic activity is reduced. Among them, the catalyst doped with promoter Cr has better catalytic activity. When the reaction conditions are 260℃, n(CH₃OH):n(H₂O)=1:1.2 and the space velocity of methanol vapor gas is 1760 h^-1, the final conversion can reach 100%, the CO content in reforming tail gas is 0.15%. Compared with CuO/CeO₂ catalyst, the conversion rate is increased by 10%, and the CO content in reforming tail gas is reduced by 0.34%.