Abstract: A series of V₂O₅ doped Ti-Ce-pillared clays (V₂O₅/Ti-Ce-PILC) were prepared and characterized by XRD, nitrogen physisorption, FT-IR, XPS, H₂-TPR, TG and NH₃-TPD. The catalytic performance of V₂O₅/Ti-Ce-PILC in the selective oxidation of H₂S was investigated in a fixed bed reactor. The results illustrated that 5%V₂O₅ doped Ti-Ce-pillared clays performs well at 180℃ in the selective oxidation of H₂S, which can be ascribed to the interaction among V₂O₅, TiO₂ and CeO₂. CeO₂ can enhance the catalyst thermostability and supply more lattice oxygen, which is of benefits to the redox of V₂O₅ and the decrease of reaction temperature. Meanwhile, the addition of TiO₂ may promote the reoxidation of VO_x and CeO_x and reduce the sulfate coverage, which can then postpone the catalyst deactivation.